HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 69346032, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-chloro-2-methyl-1H-indole-7-carboxylic acid | HCID 69346914 | — |
| Reactant | HCID 69347479 | HCID 69347479 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 69346032 | HCID 69346032 | 98% |
Reaction Steps
The title compound was synthesized in analogy to 5-chloro-2-methyl-1H-indole-7-carboxylic acid (described in example S85) using 5-chloro-2-ethyl-1H-indole-7-carboxylic acid methyl ester (80 mg, 0.34 mmol) and 1N NaOH(aq) (505 μl, 0.51 mmol) in MeOH (5 ml). The desired product (74 mg, 98%) was isolated without further purification. MS (ISP) 222.3 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259183B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-94969870fd9a4ba49ab45d092e26c9d8 |
| Source note | uspto-grants-2007_08 |