反应详情

To a solution of 59 mg (0.33 mmol) of 4-fluoro-1H-indole-7-carboxylic acid and 86 mg (0.3 mmol) of (4-tert-butyl-benzyl)-[2-(4-fluoro-phenyl)-ethyl]-amine in 3 ml DCM 63 mg (0.33 mmol) of EDC.HCl were added and the reaction mixture was stirred over night at rt. The product was purified by column chromatography (20 g silica gel; heptane/EtOAc 4:1) to yield 96 mg (72%) product as a colorless viscous oil. MS (ISP) 447.4 (M+H)+.

1. customThe product was purified by column chromatography (20 g silica gel; heptane/EtOAc 4:1)