HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 86603118, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | (4-Tert-butyl-benzyl)-(2-pyridin-4-yl-ethyl)-amine | HCID 60913740 | — |
| Reactant | 5-chloro-1H-indole-7-carboxylic acid | HCID 66868563 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86603118 | HCID 86603118 | 47.1% |
Reaction Steps
268 mg (1 mmol) of (4-tert-butyl-benzyl)-(2-pyridin-4-yl-ethyl)-amine, 196 mg (1 mmol) of 5-chloro-1H-indole-7-carboxylic acid and 217 mg (1.1 mmol) of EDC.HCl were stirred over night at rt in 20 ml DCM. The product was purified by column chromatography (silica gel; EtOAc) to yield 210 mg (47%) product as a colorless oil. MS (ISP) 446.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259183B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-72dd88f826bc4db481b093344c5edebe |
| Source note | uspto-grants-2007_08 |