反应详情

59 mg (0.33 mol) 4-fluoro-1H-indol-7-carboxylic acid, 101 mg (0.30 mmol) of (4-tert-butyl-benzyl)-[2-(3-trifluoromethyl-phenyl)-ethyl]-amine and 63 mg (0.33 mmol) of EDC.HCl were dissolved in 3 ml DCM. The reaction mixture was stirred at rt over night. The solvent was evaporated and the residue was purified by column chromatography (20 g silica gel; heptane/EtOAc 4:1) to yield 120 mg (81%) product as a colorless viscous oil. MS (ISP) 497.3 (M+H)+.

1. customThe solvent was evaporated
2. customthe residue was purified by column chromatography (20 g silica gel; heptane/EtOAc 4:1)