反应详情

87 mg (0.44 mol) of 5,6-difluoro-1H-indol-7-carboxylic acid, 106 mg (0.40 mmol) of (4-tert-butyl-benzyl)-[2-phenyl-ethyl]-amine and 84 mg (0.44 mmol) of EDC.HCl were dissolved in 4 ml DCM. The reaction mixture was stirred at rt over night. The solvent was evaporated and the residue was purified by column chromatography (20 g silica gel; heptane/EtOAc 4:1) to yield 59 mg (33%) product as a colorless viscous oil. MS (ISP) 447.2 (M+H)+.

1. customThe solvent was evaporated
2. customthe residue was purified by column chromatography (20 g silica gel; heptane/EtOAc 4:1)