HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → 11beta-Fluoro-3-methoxy-7alpha-methylestra-3,5-dien-17-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | HCID 10193144 | HCID 10193144 | — |
| Solvent | 2,2-Dimethoxypropane | HCID 6495 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 11beta-Fluoro-3-methoxy-7alpha-methylestra-3,5-dien-17-one | HCID 69332952 | 789.2% |
Reaction Steps
A solution of 2 g of 11β-fluoro-7α-methylestr-4-ene-3,17-dione in 20 ml 2,2-di-methoxypropane was stirred with 200 mg of pyridinium tosylate for 6.5 hours at 80° C. Then, it was diluted with ethyl acetate, washed with sodium bicarbonate solution and sodium chloride solution, dried on sodium sulfate and concentrated by evaporation in a vacuum. 2 g of crude 11β-fluoro-3-methoxy-7α-methylestra-3,5-dien-17-one was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07262023B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-7f25abc367b147e4b979bfc1d1e0252f |
| Source note | uspto-grants-2007_08 |