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HRID855482

反应详情

EQUATION

反应方程式

HRID 855482 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1
HCID466102

未命名化合物

结构：C[C@@H]1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CCC(=O)[C@@]1(C)C[C@@H]2F
HCID10193144

未命名化合物

PRODUCTS

生成物

1
结构：COC1=CC2=C[C@@H](C)[C@@H]3[C@H]([C@@H](F)C[C@]4(C)C(=O)CC[C@@H]34)[C@H]2CC1
HCID69332952

未命名化合物

收率 789.2%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：COC(C)(C)OC
溶剂HCID6495

2,2-Dimethoxypropane

C5H12O2

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

A solution of 2 g of 11β-fluoro-7α-methylestr-4-ene-3,17-dione in 20 ml 2,2-di-methoxypropane was stirred with 200 mg of pyridinium tosylate for 6.5 hours at 80° C. Then, it was diluted with ethyl acetate, washed with sodium bicarbonate solution and sodium chloride solution, dried on sodium sulfate and concentrated by evaporation in a vacuum. 2 g of crude 11β-fluoro-3-methoxy-7α-methylestra-3,5-dien-17-one was obtained.

WORKUP

后处理

  1. washwashed with sodium bicarbonate solution and sodium chloride solution
  2. customdried on sodium sulfate
  3. concentrationconcentrated by evaporation in a vacuum