Methylamine → HCID 69424926, compound

HRID 855498Notes

Reaction equation

HRID 855498 reaction equation
[CH3:1][NH2:2].[I:3][C:4]1[N:5]=[C:6]([NH2:22])[C:7]2[N:8]=[CH:9][N:10]([C:20]=2[N:21]=1)[C@@H:11]1[O:19][C@H:16]([CH2:17][OH:18])[C@@H:14]([OH:15])[C@H:12]1[OH:13]>CO>[I:3][C:4]1[N:21]=[C:20]2[C:7](=[N:8][CH2:9][N:10]2[C@@H:11]2[O:19][C@H:16]([CH2:17][OH:18])[C@@H:14]([OH:15])[C@H:12]2[OH:13])[C:6]([NH:2][CH3:1])([NH2:22])[N:5]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 1696622-Iodoadenosine

Product 1

HCID 69424926HCID 69424926, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 40% aqueous methylamine (1 mL) and 2-iodoadenosine (100 mg) in methanol (2 mL) was stirred at room temperature for 12 hours. The precipitate was filtered off, washed with ether and dried under vacuum to afford 2-iodo-6-methylamino adenosine, a compound of formula (11).

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with ether
  3. customdried under vacuum

Sources & evidence

ORD record
ord-fdaef98d1ae04ed49cdf1b22e883e169
Source dataset
uspto-grants-2007_08
Patent number
US07262176B2

Reaction notes

Loading…