HCID 58935450, compound → HCID 58935445, compound

HRID 855507Notes

Reaction equation

HRID 855507 reaction equation
[CH2:1]([N:8]1[C:13](=[O:14])[C:12]2[N:15]=[C:16](Br)[S:17][C:11]=2[N:10]=[C:9]1[CH:19]([NH:22][CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[CH2:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.[Pd]>[CH2:1]([N:8]1[C:13](=[O:14])[C:12]2[N:15]=[CH:16][S:17][C:11]=2[N:10]=[C:9]1[CH:19]([NH:22][CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[CH2:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 58935450HCID 58935450, compound

Product 1

HCID 58935445HCID 58935445, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 6-benzyl-2-bromo-5-(1-{[2-(dimethylamino)-ethyl]amino}propyl)[1,3]thiazolo[5,4-d]pyrimidin-7(6H)-one (1-3, 1 equiv) and 10% Pd/C in ethanol is hydrogenated at 1 atm. for 3 h. The mixture is filtered and the filtrate is concentrated to provide 6-benzyl-5-(1-{[2-(dimethylamino)ethyl]amino}propyl)[1,3]thiazolo[5,4-d]pyrimidin-7(6H)-one (1-4).

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-e02164a5a2f342859c9bb3a6269592d4
Source dataset
uspto-grants-2007_08
Patent number
US07262187B2

Reaction notes

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