反应详情

A suspension of 810 mg (2.40 mmol) of the compound obtained in Step C and 1.95 g (9.12 mmol) of NaIO4 in a mixture of 25 ml of acetone and 7 ml of 1M aqueous ammonium acetate solution is stirred for 24 hours at ambient temperature. The solid is filtered off and rinsed with copious amounts of acetone. The filtrate is concentrated by half and the residual solution is extracted with AcOEt. The organic phase is washed (saturated NaCl solution) and dried (MgSO4) to yield, after evaporation in vacuo, the title compound.

1. filtrationThe solid is filtered off
2. washrinsed with copious amounts of acetone
3. concentrationThe filtrate is concentrated by half
4. extractionthe residual solution is extracted with AcOEt
5. washThe organic phase is washed (saturated NaCl solution)
6. dry with materialdried (MgSO4)
7. customto yield
8. customafter evaporation in vacuo