2-Aminothiazole → HCID 10424957, compound

HRID 855542Notes

Reaction equation

HRID 855542 reaction equation
[CH:1]1([CH2:6][CH:7]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[C:8]([OH:10])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[S:17]1[CH:21]=[CH:20][N:19]=[C:18]1[NH2:22]>>[CH:1]1([CH2:6][CH:7]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[C:8]([NH:22][C:18]2[S:17][CH:21]=[CH:20][N:19]=2)=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 58935701HCID 58935701, compound

Product 1

HCID 10424957HCID 10424957, compound

Procedure

Employing the protocol described in EXAMPLE 1, 3-cyclopentyl-2-pyridin-3-ylpropionic acid (Preparation 2, 0.96 g, 4.4 mmol) was condensed with thiazol-2-ylamine (0.88 g, 8.8 mmol) to give the title compound: RTA=3.05 min; m/z (ES+)=302.0 [M+H]+.

Sources & evidence

ORD record
ord-7e70eff3526c4424bdb2b758d7417f13
Source dataset
uspto-grants-2007_08
Patent number
US07262196B2

Reaction notes

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