反应详情

温度

89 °C

A suspension of the 2-[(N-phenylcarbamoyl)methyl]prop-2-enoic acid (700 mg, 3.41 mmol) in Ac2O (15 mL) was then treated with NaOAc (327 mg, 3.98 mmol) and shaken for 14 hours at 89° C. The resulting clear solution was dried on a Savant™, dissolved in EtOAc and washed with H2O and brine. The organic layers were then dried down on Savant™ to yield 3-methylene-1-phenylazolidine-2,5-dione, a compound of formula (7′).

1. customThe resulting clear solution was dried on a Savant™
2. dissolutiondissolved in EtOAc
3. washwashed with H2O and brine
4. customThe organic layers were then dried down on Savant™