Sodium Acetate → 2,5-Pyrrolidinedione, 3-methylene-1-phenyl-

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A suspension of the 2-[(N-phenylcarbamoyl)methyl]prop-2-enoic acid (700 mg, 3.41 mmol) in Ac2O (15 mL) was then treated with NaOAc (327 mg, 3.98 mmol) and shaken for 14 hours at 89° C. The resulting clear solution was dried on a Savant™, dissolved in EtOAc and washed with H2O and brine. The organic layers were then dried down on Savant™ to yield 3-methylene-1-phenylazolidine-2,5-dione, a compound of formula (7′).

Herkunft & Nachweise