関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 6-Amino-3-oxo-2,3-dihydro-indazole-1-carboxylic acid tert-butyl ester | HCID 57498019 | — |
| 反応物 | HCID 178439368 | HCID 178439368 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | HCID 178439373 | HCID 178439373 | — |
反応手順
To a solution of (2-chloro-quinazolin-4-yl)-(5-isopropyl-2H-pyrazol-3-yl)-amine (50 mg, 0.17 mmol) in NMP (1 mL) was added 6-amino-3-oxo-2,3-dihydro-indazole-1-carboxylic acid tert-butyl ester (65 mg, 0.26 mmol). The mixture was heated at 130° C. for 3 hrs, cooled to room temperature, and then poured into water. The crude material was collected by filtration and treated with TFA in CH2Cl2 for 30 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07262200B2 |
|---|
| 出典データセット | uspto-grants-2007_08 |
|---|
| ORD ID | ord-104112265cc44fd0bc10f375dd282a4d |
|---|
| 出典メモ | uspto-grants-2007_08 |
|---|
