HCID 57498037, compound → 5-Phenyluracil

HRID 855647Notes

Reaction equation

HRID 855647 reaction equation
C[O:2][C:3]1[N:8]=[C:7]([O:9]C)[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:5][N:4]=1>Cl>[C:11]1([C:6]2[C:7](=[O:9])[NH:8][C:3](=[O:2])[NH:4][CH:5]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 1

HCID 57498037HCID 57498037, compound

Product 1

HCID 2871105-PhenyluracilYield 80%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2,4-Dimethoxy-5-phenyl-pyrimidine was suspended in 6N HCl and heated to 100 C for 24 h. Solution was cooled in an ice bath to afford title compound as a white solid 119 mg (80% yield). HNMR (500 MHz, dmso); δ11.25 (1H, s), 11.15 (1H, d), 7.65 (1H, d), 7.55 (2H, d), 7.35 (2H, m), 7.25 (1H, t).

Workup

  1. temperatureheated to 100 C for 24 h
  2. temperatureSolution was cooled in an ice bath

Sources & evidence

ORD record
ord-2c016508f60c42b5b2ff7c2c37e45d1a
Source dataset
uspto-grants-2007_08
Patent number
US07262200B2

Reaction notes

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