Hydrazine → HCID 17942754, compound

HRID 855734Notes

Reaction equation

HRID 855734 reaction equation
[CH:1]1([CH2:6][CH2:7][C:8]([CH:10]2C(=O)OC(C)(C)O[C:11]2=[O:19])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:20][NH2:21]>C(O)C>[CH:1]1([CH2:6][CH2:7][C:8]2[CH2:10][C:11](=[O:19])[NH:21][N:20]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 17942764HCID 17942764, compound

Product 1

HCID 17942754HCID 17942754, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-(3-cyclopentylpropionyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (900 mg, 3.3 mmol) in ethanol (5 ml) containing hydrazine (0.43 ml, 8.84 mmol) was stirred at ambient temperature for 20 minutes followed by stirring for 2 hours at 75° C. The volatiles were removed under vacuum and the residue was triturated with ether. The solid was collected by filtration, washed with ether and dried under vacuum to give 3-(2-cyclopentylethyl)-4,5-dihydro-1H-pyrazol-5-one (250 mg, 42%).

Workup

  1. stirringby stirring for 2 hours at 75° C
  2. customThe volatiles were removed under vacuum
  3. customthe residue was triturated with ether
  4. filtrationThe solid was collected by filtration
  5. washwashed with ether
  6. customdried under vacuum

Sources & evidence

ORD record
ord-807ba149901f44dd9ff82da2aa42158b
Source dataset
uspto-grants-2007_08
Patent number
US07262201B1

Reaction notes

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