Hydrazine → HCID 17942754, compound

Participants

Reaction Steps

A solution of 5-(3-cyclopentylpropionyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (900 mg, 3.3 mmol) in ethanol (5 ml) containing hydrazine (0.43 ml, 8.84 mmol) was stirred at ambient temperature for 20 minutes followed by stirring for 2 hours at 75° C. The volatiles were removed under vacuum and the residue was triturated with ether. The solid was collected by filtration, washed with ether and dried under vacuum to give 3-(2-cyclopentylethyl)-4,5-dihydro-1H-pyrazol-5-one (250 mg, 42%).

Provenance & Evidence