4-Amino-1-methylpiperidine → HCID 178465947, compound

HRID 855767Notes

Reaction equation

HRID 855767 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13](=[O:15])[CH3:14])=[CH:10][CH:11]=2)[C:6](=[C:16]([C:19]2[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=2)OC)[C:5]1=[O:28])(=[O:3])[CH3:2].[NH2:29][CH:30]1[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]1>CN(C)C=O>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13](=[O:15])[CH3:14])=[CH:10][CH:11]=2)[C:6](=[C:16]([C:19]2[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=2)[NH:29][CH:30]2[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]2)[C:5]1=[O:28])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 27375314-Amino-1-methylpiperidineHCID 68996206HCID 68996206, compound

Product 1

HCID 178465947HCID 178465947, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.7 g (7 mmol) 1,5-diacetyl-3-[4-nitrophenyl-methoxy-methylidene]-2-indolinone (Ex. VI.2) are suspended in 20 ml of dimethylformamide and stirred with 0.9 g (7.7 mmol) 4-amino-N-methylpiperidine for 6 h at 80° C. Then the mixture is evaporated down and the acetyl-protected intermediate product is washed with a little water and suction filtered.

Workup

  1. customThen the mixture is evaporated down
  2. washthe acetyl-protected intermediate product is washed with a little water and suction
  3. filtrationfiltered

Sources & evidence

ORD record
ord-b0ede62bd1a143c5bd7fe6290f7a144e
Source dataset
uspto-grants-2007_08
Patent number
US07262206B2

Reaction notes

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