Oxalyl chloride → 2-Chloro-4,5-difluorobenzoyl Isocyanate

HRID 855782Notes

Reaction equation

HRID 855782 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:14](Cl)=[O:15]>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([N:6]=[C:14]=[O:15])=[O:5]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 23171512-Chloro-4,5-difluorobenzamide

Product 1

HCID 115575832-Chloro-4,5-difluorobenzoyl Isocyanate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Chloro-4,5-difluorobenzamide was dissolved in dichloromethane, mixed with 1.5 eq. of oxalyl chloride and heated to reflux for 16 hours. The reaction mixture was concentrated under high vacuum and employed in stage b without further purification.

Workup

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. concentrationThe reaction mixture was concentrated under high vacuum
  4. customemployed in stage b without further purification

Sources & evidence

ORD record
ord-731fb258ae464be8b902cd5ec5eb23e4
Source dataset
uspto-grants-2007_08
Patent number
US07262220B2

Reaction notes

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