Hydrochloric Acid → 1-(Pyridin-2-yl)piperidin-4-amine

HRID 855842Notes

Reaction equation

HRID 855842 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)(C)(C)C.Cl>O1CCOCC1>[N:11]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 537924442-(4-Boc-Aminopiperidino)pyridine

Product 1

HCID 101979341-(Pyridin-2-yl)piperidin-4-amine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a stirred solution of (3,4,5,6-tetrahydro-2H-(1,2′)bipyridinyl-4-yl)-carbamic acid tert-butyl ester (0.45 g, 1.49 mmol) in dioxane (3.0 mL) at room temperature was added 4M HCl in dioxane (8 mL). The reaction mixture was stirred at room temperature 30 minutes. The reaction mixture was concentrated under reduced pressure, and the residue treated with ether. The titled compound was collected by filtration. MS (CI) m/z 203 (M+1)+.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionthe residue treated with ether
  3. filtrationThe titled compound was collected by filtration

Sources & evidence

ORD record
ord-df1a94e1f93d48f4aa553b4686374da8
Source dataset
uspto-grants-2007_08
Patent number
US07262207B2

Reaction notes

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