反应详情

To a solution of phosphorous (V) sulfide (6.54 mmoles) in formamide (102 mmoles; 4.08 ml), a toluene solution (8.2 ml) of 11-bromo-11H-dibenzo[b,f]oxepin-10-one (4.60 mmoles) was added. The reaction mixture was heated under stirring and refluxing for 4 hours. Then the reaction mixture was neutralized with 10% sodium hydroxide and extracted with chloroform. After purification by chromatography on a silica gel column, a crystalline product was isolated.

1. temperatureThe reaction mixture was heated
2. temperaturerefluxing for 4 hours
3. extractionextracted with chloroform
4. customAfter purification by chromatography on a silica gel column
5. customa crystalline product was isolated