Formamide → HCID 10083518, compound

Participants

Reaction Steps

To a solution of phosphorous (V) sulfide (6.54 mmoles) in formamide (102 mmoles; 4.08 ml), a toluene solution (8.2 ml) of 11-bromo-11H-dibenzo[b,f]oxepin-10-one (4.60 mmoles) was added. The reaction mixture was heated under stirring and refluxing for 4 hours. Then the reaction mixture was neutralized with 10% sodium hydroxide and extracted with chloroform. After purification by chromatography on a silica gel column, a crystalline product was isolated.

Provenance & Evidence