Hydrochloric Acid → Sodium difluorosulfoacetate

HRID 855980Notes

Reaction equation

HRID 855980 reaction equation
[OH-:1].[Na+:2].[F:3][C:4]([F:13])([S:9](F)(=[O:11])=[O:10])[C:5]([O:7]C)=[O:6].Cl>O>[F:3][C:4]([F:13])([S:9]([OH:1])(=[O:11])=[O:10])[C:5]([O-:7])=[O:6].[Na+:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 547667Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate

Product 1

HCID 86607434Sodium difluorosulfoacetate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

424 Parts of 30% aqueous sodium hydroxide solution was added into a mixture of 500 parts of methyl difluoro(fluorosulfonyl)acetate and 750 parts of ion-exchanged water in a ice bath. The added mixture was heated and refluxed at 100° C. for 2.5 hours. After cooling, the cooled mixture was neutralized with 440 parts of conc. hydrochloric acid and concentrated to obtain 802.82 parts of sodium difluorosulfoacetate (containing inorganic salt, purity: 64.2%).

Workup

  1. temperatureThe added mixture was heated
  2. temperatureAfter cooling
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-e572514320534811afdc86e24f53fdb9
Source dataset
uspto-grants-2007_08
Patent number
US07262321B2

Reaction notes

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