Benzene, 1-bromo-4-(trifluoromethyl)- → Ethyl 1-[4-(trifluoromethyl)phenyl]piperidine-4-carboxylate

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Reaction Steps

Using 4-bromobenzotrifluoride (3.15 g, 13.99 mmol) and ethyl isonipecotate (2.2 g, 13.99 mmol), ethyl 1-(4-trifluoromethylphenyl)piperidine-4-carboxylate (3.18 g, yield 74%) as a pale brown crystalline powder was prepared in the same manner as described in Reference Example 21.

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