Benzene, 1-bromo-4-(trifluoromethyl)- → Ethyl 1-[4-(trifluoromethyl)phenyl]piperidine-4-carboxylate

HRID 856030Notes

Reaction equation

HRID 856030 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=1.[NH:12]1[CH2:22][CH2:21][CH:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:14][CH2:13]1>>[F:9][C:8]([F:11])([F:10])[C:5]1[CH:6]=[CH:7][C:2]([N:12]2[CH2:22][CH2:21][CH:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:14][CH2:13]2)=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-HCID 70770Ethyl 4-piperidinecarboxylate

Product 1

HCID 23081565Ethyl 1-[4-(trifluoromethyl)phenyl]piperidine-4-carboxylateYield 75.4%

Procedure

Using 4-bromobenzotrifluoride (3.15 g, 13.99 mmol) and ethyl isonipecotate (2.2 g, 13.99 mmol), ethyl 1-(4-trifluoromethylphenyl)piperidine-4-carboxylate (3.18 g, yield 74%) as a pale brown crystalline powder was prepared in the same manner as described in Reference Example 21.

Sources & evidence

ORD record
ord-a09060f8fd794367a7b24785346ae6bf
Source dataset
uspto-grants-2007_08
Patent number
US07262212B2

Reaction notes

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