反应详情

A mixture of tert-butyl 4-[3-(tetrahydropyran-2-yloxy)phenyl]piperazine-1-carboxylate (5.20 g, 14.4 mmol) prepared in Reference Example 199 and a catalytic amount of pyridinium p-toluene sulfonate in ethanol (100 ml) was stirred at 70° C. for 1.5 hours. The reaction mixture was concentrated under reduced pressure, and methylene chloride and a saturated sodium hydrogencarbonate aqueous solution were added to the residue, which was stirred for a while. The resulting precipitates were collected by filtrasion, and then dried in vacuo to afford tert-butyl 4-(3-hydroxyphenyl)piperazine-1-carboxylate (3.73 g, yield 93%) as a a pale brown powder.

1. customprepared in Reference Example 199
2. concentrationThe reaction mixture was concentrated under reduced pressure, and methylene chloride
3. additiona saturated sodium hydrogencarbonate aqueous solution were added to the residue, which
4. customThe resulting precipitates
5. customwere collected by filtrasion
6. customdried in vacuo