反应详情

Tert-butyl 4-[1-(4-trifluoromethoxyphenyl)-piperidin-4-yl]piperazine-1-carboxylate (1 g, 2.33 mmol) was dissolved in methylene chloride (10 ml), to which trifluoroacetic acid (10 ml) was added while cooling in an ice-bath, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was washed with a 25% sodium hydroxide aqueous solution (40 ml) and brine (10 ml), and dried over sodium sulfate. After filtration, the filtrate was concentrated to afford 1-[1-(4-trifluoromethoxyphenyl)piperidin-4-yl]piperazine (770 mg, quantitative) as a yellow amorphous form.

1. additionwas added
2. temperaturewhile cooling in an ice-bath
3. washThe reaction mixture was washed with a 25% sodium hydroxide aqueous solution (40 ml) and brine (10 ml)
4. dry with materialdried over sodium sulfate
5. filtrationAfter filtration
6. concentrationthe filtrate was concentrated