Sodium Hydroxide → 1-(4-Chlorophenyl)piperazine

HRID 856307Notes

Reaction equation

HRID 856307 reaction equation
Cl.Cl.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[OH-].[Na+]>>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 12212341Piperazine, 1-(4-chlorophenyl)-, hydrochloride (1:2)

Product 1

HCID 974781-(4-Chlorophenyl)piperazine

Procedure

1-(4-Chlorophenyl)piperazine dihydrochloride (1.31 g, 4.86 mmol) was added to a sodium hydroxide solution, and the resulting mixture was extracted with methylene chloride. The extract was dried over sodium sulfate and then filtered. The filtrate was concentrated under reduced pressure to afford 1-(4-chlorophenyl)piperazine.

Workup

  1. extractionthe resulting mixture was extracted with methylene chloride
  2. dry with materialThe extract was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-cdccabf4403f48dfa68f82237959da2f
Source dataset
uspto-grants-2007_08
Patent number
US07262212B2

Reaction notes

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