HCID 22938783, compound → HCID 22938670, compound

HRID 856608Notes

Reaction equation

HRID 856608 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][C:5]=1[CH:13]([C:15]1[CH:20]=[C:19]([CH3:21])[CH:18]=[CH:17][N:16]=1)[OH:14])[CH3:2]>C(O)C.[C].[Pd]>[NH2:10][C:8]1[CH:7]=[CH:6][C:5]([CH:13]([C:15]2[CH:20]=[C:19]([CH3:21])[CH:18]=[CH:17][N:16]=2)[OH:14])=[C:4]([O:3][CH2:1][CH3:2])[CH:9]=1

Participants

4

Reactant 1

HCID 22938783HCID 22938783, compound

Product 1

HCID 22938670HCID 22938670, compoundYield 99.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

(2-ethoxy-4-nitrophenyl)(4-methylpyridin-2-yl)methanol (1.9 g) was dissolved in ethanol (100 ml), and the solution was reduced by catalytic hydrogenation with 10% palladium-carbon (0.2 g) of 50% hydration overnight. The catalyst was removed, and the solvent of the filtrate was evaporated to give (4-amino-2-ethoxyphenyl)(4-methylpyridin-2-yl)methanol (1.7 g) as colorless crystals.

Workup

  1. customThe catalyst was removed
  2. customthe solvent of the filtrate was evaporated

Sources & evidence

ORD record
ord-9232da4786924d8eaef1edaf2fc01367
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

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