反应详情

5-nitro-2-(4-propyl-4H-1,2,4-triazol-3-yl)methylthiopyridine (4.0 g), reduced iron (4.0 g), and calcium chloride (0.79 g) was added to 85% aqueous solution of ethanol (100 ml), and the mixture was refluxed for 3 hours. The reaction solution was filtered with Celite, and the solvent of the filtrate was distilled off. The residue was purified by basic silica gel column chromatography (elution solvent: methanol/ethyl acetate), to give 5-amino-2-(4-propyl-4H-1,2,4-triazol-3-yl)methylthiopyridine (3.3 g) as red oil.

1. temperaturethe mixture was refluxed for 3 hours
2. filtrationThe reaction solution was filtered with Celite
3. distillationthe solvent of the filtrate was distilled off
4. customThe residue was purified by basic silica gel column chromatography (elution solvent: methanol/ethyl acetate)