HCID 69523111, compound → HCID 69521295, compound

HRID 856625Notes

Reaction equation

HRID 856625 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][N:13]2[CH:17]=[N:16][N:15]=[CH:14]2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][N:13]2[CH:14]=[N:15][N:16]=[CH:17]2)=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 69523111HCID 69523111, compound

Product 1

HCID 69521295HCID 69521295, compoundYield 95.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-[3-(4-nitrophenyl)propyl]-4H-1,2,4-triazole (1.2 g) was dissolved in ethanol (100 ml), 10% palladium-activated carbon (50% hydration, 0.2 g) was added to the solution at room temperature, and the solution was reduced by catalytic hydrogenation overnight. The catalyst was removed. The solvent of the filtrate was distilled off, to give 4-[3-(4-aminophenyl)propyl]-4H-1,2,4-triazole (1.0 g) as colorless crystals.

Workup

  1. customThe catalyst was removed
  2. distillationThe solvent of the filtrate was distilled off

Sources & evidence

ORD record
ord-6b73b53f496a496783a45c5d70e3f765
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

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