Methanol → HCID 178498891, compound

HRID 856714Notes

Reaction equation

HRID 856714 reaction equation
C[C:2]#[C:3][C:4]([O-:6])=[O:5].C[Si]([N:11]=[N+:12]=[N-:13])(C)C.[CH3:14]O>>[NH:11]1[CH:2]=[C:3]([C:4]([O:6][CH3:14])=[O:5])[N:13]=[N:12]1

Participants

4

Reactant 3

HCID 887MethanolHCID 78378AzidotrimethylsilaneHCID 6994510HCID 6994510, compound

Product 1

HCID 178498891HCID 178498891, compound

Conditions

Temperature
105 °C

Procedure

Methylpropiolate (20 g) and trimethylsilyl azide (68.6 g) were added to a pressure-resistant tube, and the mixture was stirred for 72 hours at 105° C. After allowing the mixture to be cooled to room temperature, methanol was added to the mixture, and the solvent was removed under reduced pressure, and the obtained residue was washed with diethylether/methanol to give methyl 1,2,3-triazole-4-carboxylate (22.7 g).

Workup

  1. temperatureto be cooled to room temperature
  2. customthe solvent was removed under reduced pressure
  3. washthe obtained residue was washed with diethylether/methanol

Sources & evidence

ORD record
ord-bb5e55f2827b490c9a28801e2218d0b7
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

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