Thionyl Chloride → HCID 18670786, compound

HRID 856737Notes

Reaction equation

HRID 856737 reaction equation
O[CH2:2][C:3]1[N:7]([CH2:8][CH2:9][O:10][CH3:11])[CH:6]=[N:5][CH:4]=1.S(Cl)([Cl:14])=O>>[ClH:14].[Cl:14][CH2:2][C:3]1[N:7]([CH2:8][CH2:9][O:10][CH3:11])[CH:6]=[N:5][CH:4]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 18670918[1-(2-Methoxyethyl)-1H-imidazol-5-yl]methanol

Product 1

HCID 18670786HCID 18670786, compound

Conditions

Temperature
80 °C

Procedure

5-hydroxymethyl-1-(2-methoxyethyl)imidazole (2.8 g) was added to thionyl chloride (8.4 ml), and the mixture was stirred for 1 hour at 80° C. The solvent was removed under reduced pressure, and the obtained residue was washed with ethyl acetate, to give 5-chloromethyl-1-(2-methoxyethyl)imidazole hydrochloride (3.2 g).

Workup

  1. customThe solvent was removed under reduced pressure
  2. washthe obtained residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-35523e6fbde34cf2bb7fd1665815d0e8
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

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