Thionyl Chloride → HCID 22938853, compound

HRID 856756Notes

Reaction equation

HRID 856756 reaction equation
[CH:1]1([CH2:4][N:5]2[CH:9]=[CH:8][N:7]=[C:6]2[CH2:10]O)[CH2:3][CH2:2]1.S(Cl)([Cl:14])=O>>[ClH:14].[Cl:14][CH2:10][C:6]1[N:5]([CH2:4][CH:1]2[CH2:3][CH2:2]2)[CH:9]=[CH:8][N:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 229387391-(Cyclopropylmethyl)-1H-imidazole-2-methanol

Product 1

HCID 22938853HCID 22938853, compound

Conditions

Temperature
90 °C

Procedure

To 1-cyclopropylmethyl-2-hydroxymethylimidazole (2.50 g) was added thionyl chloride (25 ml) at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature, the solvent was distilled off under reduced pressure and the obtained solid was washed with ethyl acetate, to give 2-chloromethyl-1-cyclopropylmethylimidazole hydrochloride. (2.96 g) as brown crystals.

Workup

  1. customto be at room temperature
  2. distillationthe solvent was distilled off under reduced pressure
  3. washthe obtained solid was washed with ethyl acetate

Sources & evidence

ORD record
ord-813269d41bda4f7791b86ff74507be63
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

Loading…