Thionyl Chloride → HCID 69521313, compound

HRID 856758Notes

Reaction equation

HRID 856758 reaction equation
[CH3:1][CH:2]([N:5]1[CH:9]=[CH:8][N:7]=[C:6]1[CH2:10]O)[CH2:3][CH3:4].S(Cl)([Cl:14])=O>>[ClH:14].[CH3:1][CH:2]([N:5]1[CH:9]=[CH:8][N:7]=[C:6]1[CH2:10][Cl:14])[CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 45088406HCID 45088406, compound

Product 1

HCID 69521313HCID 69521313, compound

Conditions

Temperature
90 °C

Procedure

To 1-(2-butyl)-2-hydroxymethylimidazole (2.70 g) was added thionyl chloride (27 ml) at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure, and the obtained residue was recrystallized from ethyl acetate, to give 1-(2-butyl)-2-chloromethylimidazole hydrochloride (3.09 g) as brown crystals.

Workup

  1. customto be at room temperature
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe obtained residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-72d14560c37e42f5beffc1620c71eef2
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

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