Thionyl Chloride → HCID 22938760, compound

HRID 856759Notes

Reaction equation

HRID 856759 reaction equation
O[CH2:2][C:3]1[N:4]([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH:5]=[CH:6][N:7]=1.S(Cl)([Cl:15])=O>>[ClH:15].[Cl:15][CH2:2][C:3]1[N:4]([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 164950811-Pentyl-1H-imidazole-2-methanol

Product 1

HCID 22938760HCID 22938760, compound

Conditions

Temperature
90 °C

Procedure

To 2-hydroxymethyl-1-pentylimidazole (3.8 g) was added thionyl chloride (38 ml) at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure and the obtained residue was recrystallized from methanol-ethyl acetate, to give 2-chloromethyl-1-pentylimidazole hydrochloride (3.00 g) as brown crystals.

Workup

  1. customto be at room temperature
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe obtained residue was recrystallized from methanol-ethyl acetate

Sources & evidence

ORD record
ord-afd49df34ee3476692577cabcabf0f44
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

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