Thionyl Chloride → HCID 22938536, compound

HRID 856779Notes

Reaction equation

HRID 856779 reaction equation
O[CH2:2][C:3]1[N:4]=[CH:5][N:6]([CH2:8][CH2:9][CH3:10])[CH:7]=1.S(Cl)([Cl:13])=O>>[ClH:13].[Cl:13][CH2:2][C:3]1[N:4]=[CH:5][N:6]([CH2:8][CH2:9][CH3:10])[CH:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 124932744-Hydroxymethyl-1-propylimidazole

Product 1

HCID 22938536HCID 22938536, compound

Conditions

Temperature
90 °C

Procedure

To 4-hydroxymethyl-1-propylimidazole (2.5 g), thionyl chloride (25 ml) was added by portions at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure and the obtained residue was dissolved in methanol. The solvent was distilled off again under reduced pressure, to give 4-chloromethyl-1-propylimidazole hydrochloride (3.47 g) as brown oil.

Workup

  1. customto be at room temperature
  2. distillationThe solvent was distilled off under reduced pressure
  3. dissolutionthe obtained residue was dissolved in methanol
  4. distillationThe solvent was distilled off again under reduced pressure

Sources & evidence

ORD record
ord-2ec8e4951a9e4edeb59921e5992caa5d
Source dataset
uspto-grants-2007_08
Patent number
US07262185B2

Reaction notes

Loading…