Crotonaldehyde → alpha-(4-Difluoromethoxyphenyl)-alpha-(4-methylthioanilino)acetonitrile

HRID 856824Notes

Reaction equation

HRID 856824 reaction equation
[F:1][CH:2]([F:24])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=O)=O)=[CH:16][CH:15]=2)[C:11]#[N:12])=[CH:6][CH:5]=1.C(=O)/C=C/C>>[F:24][CH:2]([F:1])[O:3][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([S:20][CH3:23])=[CH:16][CH:15]=2)[C:11]#[N:12])=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 447466CrotonaldehydeHCID 21862740alpha-(4-Difluoromethoxyphenyl)-alpha-(4-methylsulfonylanilino)acetonitrile

Product 1

HCID 21862794alpha-(4-Difluoromethoxyphenyl)-alpha-(4-methylthioanilino)acetonitrile

Procedure

Following a procedure similar to that described in Example 1(iii), but using α-(4-difluoromethoxyphenyl)-α-(4-methylsulfonylanilino)acetonitrile [prepared as described in step (ii) above] and crotonaldehyde as starting materials, the title compound was obtained as a white powder (yield 31%), melting at 98-99° C.

Sources & evidence

ORD record
ord-2aebb45d1c4140a6b49f0659aa90cf3d
Source dataset
uspto-grants-2006_12
Patent number
USRE039420E1

Reaction notes

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