Pyridine → HCID 54381782, compound

0.90 g (2.6 mmol) of 1-(4-mercaptophenyl)-4-methyl-2-(4-sulfamoylphenyl)-pyrrole (prepared as described in Example 129) was dissolved in 15 ml of tetrahydrofuran, and 0.27 ml (2.9 mmol) of acetic anhydride was added to the resulting solution. 0.53 ml (6.5 mmol) of pyridine was then added to the mixture, which was then stirred at room temperature overnight. The reaction mixture was then concentrated by evaporation under reduced pressure, and a saturated aqueous solution of sodium hydrogencarbonate was added to the residue. The resulting mixture was then extracted with ethyl acetate. The organic extract was washed with water and dried over anhydrous magnesium sulfate, after which it was concentrated by evaporation under reduced pressure. The residue thus obtained was applied to a silica gel chromatography column and eluted with a 3:2 by volume mixture of hexane and ethyl acetate, to give 0.44 g (yield 43%) of the title compound as a white powder, melting at 149-152° C.

1. concentrationThe reaction mixture was then concentrated by evaporation under reduced pressure
2. additiona saturated aqueous solution of sodium hydrogencarbonate was added to the residue
3. extractionThe resulting mixture was then extracted with ethyl acetate
4. extractionThe organic extract
5. washwas washed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationafter which it was concentrated by evaporation under reduced pressure
8. customThe residue thus obtained
9. washeluted with a 3:2 by volume mixture of hexane and ethyl acetate

ORD record

ord-9ef758ee697d46a381bb841477ec800b

Source dataset

uspto-grants-2006_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

USRE039420E1