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HRID856896

反应详情

EQUATION

反应方程式

HRID 856896 的结构方程式

REACTANTS

反应物

2
反应SMILES：CN
HCID6329

Methylamine

CH5N

反应SMILES：CCOC(=O)c1cnn(-c2nc(N)c3ncn([C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)c3n2)c1
HCID9865974

ethyl 1-[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]pyrazole-4-carboxylate

C16H19N7O6

PRODUCTS

产物

1
反应SMILES：CNC(=O)c1cnn(-c2nc(N)c3ncn([C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)c3n2)c1
HCID219024

Lexiscan

C15H18N8O5

CONDITIONS

反应条件

温度
65 °C

PROCEDURE

实验过程

Compound 12 (0.05 mg, 0.12 mmol) was added to 4 mL methylamine (40% sol. In water). The mixture was heated at 65° C. for 24 h. After concentration in vacuo, the residue was purified using prep. TLC (10% MeOH:DCM). 1HNMR (CD3OD) 62.90 (s, 3H), 3.78 (m, 1H), 3.91 (m, 1H), 4.13 (d, 1H), 4.34 (d, 1H), 4.64 (m, 1H), 6.06 (d, 1H), 8.11 (s, 1H), 8.38 (s, 1H), 9.05 (s, 1H).

WORKUP

后处理

  1. concentrationAfter concentration in vacuo
  2. customthe residue was purified