2',4'-Bis(trifluoromethyl)acetophenone → 2,4-Bis(trifluoromethyl)phenacyl bromide

HRID 856932Notes

Reaction equation

HRID 856932 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[CH:5][C:4]=1[C:13](=[O:15])[CH3:14].[Br:18]CC(C1C=C(Cl)C=CC=1Cl)=O>>[F:1][C:2]([F:16])([F:17])[C:3]1[CH:8]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:6]=[CH:5][C:4]=1[C:13](=[O:15])[CH2:14][Br:18]

Participants

3

Reactant 2

HCID 27360932',4'-Bis(trifluoromethyl)acetophenoneHCID 27569072-Bromo-1-(2,5-dichlorophenyl)ethanone

Product 1

HCID 27787772,4-Bis(trifluoromethyl)phenacyl bromideYield 63%

Procedure

This compound was prepared from 1-[2,4-bis(trifluoromethyl)phenyl]ethanone (5.0 g, 19.52 mmol) in the manner described for 2-bromo-1-(2,5-dichlorophenyl)ethanone, affording 4.12 g (63%) of a white solid. 1H-NMR (DMSO-d6) δ 8.28 to 8.16 (m, 3H), 4.98 (s, 2H);

Sources & evidence

ORD record
ord-02b33a90e2ef4adbb2d9313e64b350a2
Source dataset
uspto-grants-2006_12
Patent number
US07144885B2

Reaction notes

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