Methanol → HCID 482715, compound

HRID 857075Notes

Reaction equation

HRID 857075 reaction equation
[CH3:1][C:2]1[CH:27]=[CH:26][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([NH:15][S:16]([C:19]4[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=4)(=[O:18])=[O:17])=[CH:11][CH:10]=3)[S:8][C:4]=2[CH:3]=1.[CH3:28][OH:29]>>[CH3:28][O:29][C:9]1([C:7]2[S:8][C:4]3[CH:3]=[C:2]([CH3:1])[CH:27]=[CH:26][C:5]=3[N:6]=2)[CH:10]=[CH:11][C:12](=[N:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH:13]=[CH:14]1

Participants

3

Reactant 2

HCID 887MethanolHCID 1239093HCID 1239093, compound

Product 1

HCID 482715HCID 482715, compoundYield 67%

Procedure

To the sulfonamide (0.1 g) dissolved in methanol (2 mL) was added BTIB (1.1 eq.) in one portion as a solid. The resulting suspension was stirred at room temperature for 5 hours. The precipitate formed was collected on a filter, washed with ice cold methanol (2 mL) and dried under vacuum to give the title compound.

Workup

  1. additionwas added BTIB (1.1 eq.) in one portion as a solid
  2. customThe precipitate formed
  3. customwas collected on a filter
  4. washwashed with ice cold methanol (2 mL)
  5. customdried under vacuum

Sources & evidence

ORD record
ord-b9532c42da3a4e60a77d47a657366abd
Source dataset
uspto-grants-2006_12
Patent number
US07144893B2

Reaction notes

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