反应详情

Ethyl N-(3-iodobenzyl)glycinate (0.567 g) was treated with 1M HCl (3.9 ml) and sodium cyanate (0.345 g) and then refluxed for 30 min. Concentrated HCl (4.5 ml) was added and the reaction mixture refluxed again for 30 min. The reaction mixture was evaporated under reduced pressure and then triturated with EtOAc (3×20 ml). The combined extracts were dried (Na2SO4) and evaporated under reduced pressure to give the title compound (0.543 g). LCMS RT 2.63 min.

1. temperaturerefluxed for 30 min
2. temperaturethe reaction mixture refluxed again for 30 min
3. customThe reaction mixture was evaporated under reduced pressure
4. customtriturated with EtOAc (3×20 ml)
5. dry with materialThe combined extracts were dried (Na2SO4)
6. customevaporated under reduced pressure