反应详情

温度

50 °C

3-(4-Cyanoanilino)propyl 4-methylbenzenesulfonate (1.98 g, 6 mmol; see step (b) above), and tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (1.49 g, 6 mmol; see Preparation A above) was mixed with K2CO3 (1.93 g, 14 mmol) and CH3CN (100 mL) and then stirred at 50° C. overnight. The solvent was evaporated and the product was purified by chromatography on silica (DCM:MeOH (20:1)) to give 1.83 g (82%) of the sub-title compound.

1. customPreparation A above)
2. customThe solvent was evaporated
3. customthe product was purified by chromatography on silica (DCM:MeOH (20:1))