反应详情

To 112 ml of a solution of 13.38 g of ethyl 6-bromohexanoate in acetone, 26.97 g of sodium iodide was added and heated to reflux for 18 hours. The reaction solution was cooled, filtered to remove insolubles and washed with acetone. The filtrate was concentrated and, after addition of water, extracted with ethyl acetate. The organic layer was washed with water and brine sequentially, dried over anhydrous magnesium sulfate and concentrated to provide 16.21 g of the objective compound as red-yellow oil.

1. temperatureheated
2. temperatureto reflux for 18 hours
3. temperatureThe reaction solution was cooled
4. filtrationfiltered
5. customto remove insolubles
6. washwashed with acetone
7. concentrationThe filtrate was concentrated
8. additionafter addition of water
9. extractionextracted with ethyl acetate
10. washThe organic layer was washed with water and brine sequentially
11. dry with materialdried over anhydrous magnesium sulfate
12. concentrationconcentrated