{2-Fluoro-5-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-phenyl}-methanol → 2-Fluoro-5-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-benzaldehyde

HRID 857296Notes

Reaction equation

HRID 857296 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:18]([S:21]([CH3:24])(=[O:23])=[O:22])([CH3:20])[CH3:19])[CH:11]=[C:12]3[C:17]=2[N:16]=[CH:15][CH:14]=[CH:13]3)=[CH:4][C:3]=1[CH2:25][OH:26]>FC1C=CC(B(O)O)=CC=1CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:18]([S:21]([CH3:24])(=[O:23])=[O:22])([CH3:19])[CH3:20])[CH:11]=[C:12]3[C:17]=2[N:16]=[CH:15][CH:14]=[CH:13]3)=[CH:4][C:3]=1[CH:25]=[O:26]

Participants

3

Reactant 1

HCID 21865592{2-Fluoro-5-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-phenyl}-methanol

Product 1

HCID 218655642-Fluoro-5-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-benzaldehyde

Reagents, catalysts & solvents 1

HCID 218655884-Fluoro-3-(hydroxymethyl)benzeneboronic acidSolvent

Procedure

Prepared according to the oxidation procedure described in Quinoline 14 (Step 1) but using the {2-fluoro-5-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-phenyl)}-methanol from Step 2 as the starting material.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1baa6525ee1f4bedbcb6b4a42f2e0bed
Source dataset
uspto-grants-2006_12
Patent number
US07144896B2

Reaction notes

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