Methanol → HCID 10196916, compound

HRID 857297Notes

Reaction equation

[F:1][C:2]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[C:22]([C:30]([S:33]([CH3:36])(=[O:35])=[O:34])([CH3:32])[CH3:31])[CH:23]=[C:24]3[C:29]=2[N:28]=[CH:27][CH:26]=[CH:25]3)=[CH:16][C:3]=1[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([CH3:15])(=[O:14])=[O:13])=[CH:8][CH:7]=1.C(Cl)Cl.[CH3:40][OH:41]>>[F:1][C:2]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[C:22]([C:30]([S:33]([CH3:36])(=[O:34])=[O:35])([CH3:32])[CH3:31])[CH:23]=[C:24]3[C:29]=2[N:28]=[CH:27][CH:26]=[CH:25]3)=[CH:16][C:3]=1[CH2:4][N:5]([C:6]1[CH:7]=[CH:8][C:9]([S:12]([CH3:15])(=[O:13])=[O:14])=[CH:10][CH:11]=1)[C:40]([NH:5][CH:6]([CH3:11])[CH3:7])=[O:41]

Participants

Reactant 3

HCID 887Methanol

HCID 6344Dichloromethane

HCID 21865639HCID 21865639, compound

Product 1

HCID 10196916HCID 10196916, compound

Procedure

Prepared in two steps according to the procedures described in EXAMPLE 41 but using the {2-fluoro-5-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-benzyl}-(4-methanesulfonyl-phenyl)-amine from present Step 4 as the starting material. Flash chromatography (CH2Cl2:MeOH; 96:4) afforded the compound as a foam.

Workup

customPrepared in two steps

Sources & evidence

ORD record: ord-160780dc175146949da53aa5c5453595
Source dataset: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07144896B2

Reaction notes

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