Methyl[8-isopropenyl-6-(methylsulfonyl)-2,3-dihydro-1h-pyrrolo[1,2-a]indol-1-yl]acetate → Methyl[8-isopropyl-6-(methylsulfonyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

HRID 857365Notes

Reaction equation

HRID 857365 reaction equation
[CH3:1][O:2][C:3](=[O:24])[CH2:4][CH:5]1[C:9]2=[CH:10][C:11]3[C:12]([C:21]([CH3:23])=[CH2:22])=[CH:13][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:15][C:16]=3[N:8]2[CH2:7][CH2:6]1>CCO.[Pd]>[CH3:1][O:2][C:3](=[O:24])[CH2:4][CH:5]1[C:9]2=[CH:10][C:11]3[C:12]([CH:21]([CH3:22])[CH3:23])=[CH:13][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:15][C:16]=3[N:8]2[CH2:7][CH2:6]1

Participants

4

Reactant 1

HCID 90964995Methyl[8-isopropenyl-6-(methylsulfonyl)-2,3-dihydro-1h-pyrrolo[1,2-a]indol-1-yl]acetate

Product 1

HCID 131726145Methyl[8-isopropyl-6-(methylsulfonyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To the product of Step 2 (130 mg, 0.39 mmol) in EtOH (3 mL) was added Pd/C 10% (40 mg). The mixture was hydrogenated with a Parr hydrogenator at 50 psi for 45 minutes, filtered on a pad of celite, and the filtrate evaporated to dryness and used as such in the next step.

Workup

  1. filtrationfiltered on a pad of celite
  2. customthe filtrate evaporated to dryness

Sources & evidence

ORD record
ord-ae0198c4502b4bbb96c0fcbcff00c93e
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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