HCID 91379151, compound → HCID 91430685, compound

HRID 857370Notes

Reaction equation

HRID 857370 reaction equation
[CH3:1][O:2][C:3](=[O:22])[CH2:4][CH:5]1[C:9]2=[CH:10][C:11]3[C:12]([C:19]([CH3:21])=[CH2:20])=[CH:13][C:14]([O:17][CH3:18])=[CH:15][C:16]=3[N:8]2[CH2:7][CH2:6]1>CCO.[Pd]>[CH3:1][O:2][C:3](=[O:22])[CH2:4][CH:5]1[C:9]2=[CH:10][C:11]3[C:12]([CH:19]([CH3:20])[CH3:21])=[CH:13][C:14]([O:17][CH3:18])=[CH:15][C:16]=3[N:8]2[CH2:7][CH2:6]1

Participants

4

Reactant 1

HCID 91379151HCID 91379151, compound

Product 1

HCID 91430685HCID 91430685, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To the compound of Step 1 (200 mg, 0.67 mmol) in EtOH (20 mL) was added Pd/C 10% (100 mg). The mixture was hydrogenated with a Parr hydrogenator at 50 psi for 45 minutes the filtered on a pad of celite. The filtrate was evaporated to dryness and used as such in the next step (170 mg).

Workup

  1. filtrationthe filtered on a pad of celite
  2. customThe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-d7682efbd2dd4ee5bcddf5220621f35b
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

Loading…