反应详情

To a solution of (4-bromo-6-fluoro-1H-indol-2-yl)methanol (2.6 g, 11 mmol) in CH2Cl2 (100 mL) at r.t. was added Dess-Martin periodinane (6.4 g, 15 mmol). The mixture was stirred for 30 minutes at r.t. and saturated aqueous NaHCO3 was added. The mixture was filtered through a celite pad and the filtrate was extracted with CH2Cl2. The combined organic layers were dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluted with 30% EtOAc to give 2 g of the title compound.

1. filtrationThe mixture was filtered through a celite pad
2. extractionthe filtrate was extracted with CH2Cl2
3. dry with materialThe combined organic layers were dried over Na2SO4
4. concentrationconcentrated
5. customThe residue was purified by silica gel chromatography
6. washeluted with 30% EtOAc